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Articles from Wiley

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The latest papers in Chemistry Europe
Updated: 14 weeks 3 days ago

Increased Lipophilicity of Halogenated Ruthenium(II) Polypyridyl Complexes Leads to Decreased Phototoxicity in vitro when Used as Photosensitizers for Photodynamic Therapy

7 July, 2020 - 00:00

One up, one down : RuII polypyridyl complexes are prime candidates for the development of new photosensitizers for photodynamic therapy. Increasing their lipophilicity could result in improved pharmacological properties. The relationship between lipophilicity and in vitro phototoxicity of halogenated RuII complexes was investigated.

[Full Papers]
Dr. Saonli Roy, Elisa Colombo, Dr. Robin Vinck, Dr. Cristina Mari, Dr. Riccardo Rubbiani, Dr. Malay Patra, Dr. Gilles Gasser
doi.org/10.1002/cbic.202000289

Chemical Knockdown of MicroRNA with Small-Molecule Chimeras

7 July, 2020 - 00:00

Targeting “undruggable” RNA : In this concept article, we introduce the development and application of small-molecule chimeras (SMCs) to the targeted degradation of microRNAs. Due to their high specificity and potency, SMCs present an unprecedented chemical approach to knock down endogenous miRNAs, and thus should contribute to both biological discovery and therapeutic development.

[Concepts]
Yi Feng, Prof. Dr. Jinbo Li, Prof. Dr. Yan Zhang
doi.org/10.1002/cbic.202000287

Substrate-Controlled Cyclopropanation Reactions of Glycals with Aryl Diazoacetates

7 July, 2020 - 00:00

Cyclopropanation reactions of D-glucal and D-galactal derivatives with aryldiazoacetates can be conducted in a substrate-controlled, stereoselective fashion using simple Rh(II) catalysts, which is further supported by DFT studies.

[Communications]
Yujing Guo, Chao Pei, Prof. Rene M. Koenigs
doi.org/10.1002/cctc.202000569

In Situ Spectroelectrochemical Investigation of Potential-Dependent Changes in an Amphiphilic Imidazolium-Based Ionic Liquid Film on the Au(111) Electrode Surface

7 July, 2020 - 00:00

The cover shows potential-dependent changes in the orientation of an imidazolium-based ionic liquid monolayer, deposited via the Langmuir-Blodgett method, onto the Au(111) electrode surface. This bottom-up approach allows examinations of the electrical double layer of diluted ionic liquids in aqueous solution. A concerted use of electrochemical and polarization modulation infrared reflection absorption spectroscopy provides a molecular scale picture of potential-driven changes in the ionic liquid film… ” Learn more about the story behind the research featured on the front cover in this issue's Cover Profile. Read the corresponding Article at 10.1002/celc.202000385.

[Cover Profile]
Thorben Sieling, Dr. Izabella Brand
doi.org/10.1002/celc.202000845

Recent Advances in Transition Metal Phosphide Electrocatalysts for Water Splitting under Neutral pH Conditions

7 July, 2020 - 00:00

Neutral territory : Transition metal phosphides (TMPs) are emerging alternatives for the hydrogen and oxygen evolution reactions (HER and OER) under neutral pH conditions. Also, water electrolysis under neutral pH conditions is the ultimate form of utilizing the enormous water resources that exist on Earth. Herein, recent progress of electrochemical HER and OER by TMPs are reviewed, and the challenges for further improvement as promising catalysts are provided.

[Minireviews]
Dr. Byeongyoon Kim, Dr. Taekyung Kim, Prof. Kwangyeol Lee, Prof. Jinghong Li
doi.org/10.1002/celc.202000734

A Synthetic Chlorophyll Dimer Appending Fullerene: Effect of Chlorophyll Pairing on (Photo)redox Properties

7 July, 2020 - 00:00

Imitation game : A charge-separating chlorophyll dimer with a structure resembling natural chlorophyll pairs in photosynthetic reaction centers is reported. Structural, electrochemical, and spectrometric analyses revealed the similarity between the artificial and natural pair. Pairing the chlorophyll-a derivatives with an N-alkylamide group provided geometry and properties that duplicate those of the natural chlorophyll pair.

[Full Papers]
Dr. Yoshinao Shinozaki, Dr. Chiasa Uragami, Prof. Dr. Hideki Hashimoto, Prof. Dr. Hitoshi Tamiaki
doi.org/10.1002/chem.202000614

Facile Construction of Furanoacenes by a Three-Step Sequence Going through Disilyl-<i>exo</i>-cyclic Dienes

7 July, 2020 - 00:00

Furanoacenes : Facile synthesis of various benzonaphthofurans was achieved from 1,4-disilyl-2-aryloxy-1,3-enynes by hydroarylation, cycloaddition with arynes or alkenes, and desilylated aromatization. These three reactions could be operated sequentially in one-pot, being highly effective and providing a range of furanoacene products easily.

[Communications]
Dr. Yasunori Minami, Yuki Furuya, Prof. Dr. Tamejiro Hiyama
doi.org/10.1002/chem.202001119

Reactivity of Diarylnitrenium Ions

7 July, 2020 - 00:00

Nitrenium conundrum : When exploring synthetic-scale generation of stable diarylnitrenium ions, Ar2N+, we find products quite different to those derived from photochemical generation.

[Communications]
Dr. Agnes Kütt, Prof. Dr. Gunnar Jeschke, Dr. Lauri Toom, Dr. Jaak Nerut, Prof. Christopher A. Reed
doi.org/10.1002/chem.202000930

Effect of an Aromatic Solvent on Hydrogen-Bond-Directed Supramolecular Polymerization Leading to Distinct Topologies

7 July, 2020 - 00:00

Adding complexity : The use of aromatic and nonpolar solvent mixtures for supramolecular polymerization of hydrogen-bonded supermacrocycles results in complex paths attributed to the formation of competing extended hydrogen-bonded motifs.

[Full Papers]
Atsushi Isobe, Deepak D. Prabhu, Sougata Datta, Takumi Aizawa, Prof. Shiki Yagai
doi.org/10.1002/chem.202001344

Planar, Stair-Stepped, and Twisted: Modulating Structure and Photophysics in Pyrene- and Benzene-Fused N-Heterocyclic Boranes

7 July, 2020 - 00:00

Polycyclic aromatic hydrocarbons (PAHs) have become a significant building block in molecular materials chemistry. Fusion or doping of boron into PAHs is known to improve the optoelectronic properties by reducing the LUMO energy level. A comprehensive study on the syntheses, structures, and photophysical properties of a new class of fused N-heterocyclic boranes (NHBs) is reported (see figure).

[Full Papers]
Kelsie E. Krantz, Sarah L. Weisflog, Nathan C. Frey, Dr. Wenlong Yang, Dr. Diane A. Dickie, Prof. Dr. Charles Edwin Webster, Prof. Dr. Robert J. Gilliard Jr.
doi.org/10.1002/chem.202002118

Biocatalytic Micro- and Nanomotors

7 July, 2020 - 00:00

Thrust engines : Enzymes provide various artificial active structures with a thrust for their self-propulsion in different media. Current enzyme-powered micro- and nanomotors are considered progressive tools in targeted drug delivery, biosensing, and water remediation. Rapidly growing research in this field promises the advanced design of multifunctional superstructures created by self-assembling properly selected enzymes and support materials.

[Minireviews]
Dr. Soňa Hermanová, Prof. Martin Pumera
doi.org/10.1002/chem.202001244

Flexible and Epitaxial Metal Oxide Thin Film Growth by Photoreaction Processing for Electrical and Optical Applications

7 July, 2020 - 00:00

Photo finish : Photoreactions can replace conventional heating processes for growing oxide thin films from chemical solutions. Key variables in photoreactions that affect epitaxial and polycrystalline thin film growth are summarised. In addition, the features of the photoreaction process that can be controlled at a low temperature by oxygen non-stoichiometry are examined.

[Reviews]
Dr. Tetsuo Tsuchiya, Dr. Tomohiko Nakajima, Yuko Uzawa
doi.org/10.1002/chem.201905879

Rhodium(I)-NHC Complexes Bearing Bidentate Bis-Heteroatomic Acidato Ligands as <i>gem</i>-Selective Catalysts for Alkyne Dimerization

7 July, 2020 - 00:00

Flash Catalyst : Several rhodium-NHC-BHetA complexes has been prepared and compared as alkyne dimerization catalysts. The N,O framework of acetanilidato ligand is essential for a very high activity.

[Full Papers]
María Galiana-Cameo, Marina Borraz, Yaroslava Zelenkova, Dr. Vincenzo Passarelli, Prof. Fernando J. Lahoz, Prof. Jesús J. Pérez-Torrente, Prof. Luis A. Oro, Dr. Andrea Di Giuseppe, Dr. Ricardo Castarlenas
doi.org/10.1002/chem.202001584

Boosting Na<sup>+</sup> Storage Ability of Bimetallic Mo<sub><i>x </i></sub>W<sub>1−<i>x </i></sub>Se<sub>2</sub> with Expanded Interlayers

7 July, 2020 - 00:00

Sodium storage : New bimetallic Mox W1−x Se2 nanosheets with expanded interlayers decorated with N-doped carbon assembled flowerlike hierarchical microspheres (Mox W1−x Se2/NC) are synthesized through a facile room-temperature self-polymerization and subsequent selenization strategy. The resulting material has high reversible capacity, good cycling life, and excellent rate capability as the anode material for sodium-ion batteries owing to its unique structural and compositional merits (see figure).

[Full Papers]
Dr. Nianxiang Shi, Dr. Baojuan Xi, Fang Tian, Dr. Xiaojian Ma, Dr. Haibo Li, Prof. Jinkui Feng, Prof. Shenglin Xiong
doi.org/10.1002/chem.202000820

The Earlier the Better: Structural Analysis and Separation of Lanthanides with Pyrroloquinoline Quinone

7 July, 2020 - 00:00

No co-ligands required : The precipitation and solubility behavior of lanthanide complexes with pyrroloquinoline quinone (PQQ), is presented. Complexes with early lanthanides are preferentially formed with PQQ and rapidly precipitate out of aqueous solutions. The first molecular structure of a biorelevant europium PQQ complex outside a protein environment is reported and shows a Eu2PQQ2 dimer.

[Full Papers]
Dr. Henning Lumpe, Annika Menke, Prof. Dr. Christoph Haisch, Dr. Peter Mayer, Dr. Anke Kabelitz, Dr. Kirill V. Yusenko, Dr. Ana Guilherme Buzanich, Theresa Block, Prof. Dr. Rainer Pöttgen, Dr. Franziska Emmerling, Prof. Dr. Lena J. Daumann
doi.org/10.1002/chem.202002653

Oxidation of <i>cis</i>-Diamminediacetato Pt<sup>II</sup> with Hydrogen Peroxide Can Give Rise to Two Isomeric Pt<sup>IV</sup> Products

7 July, 2020 - 00:00

Oxidation of PtII diamminediacetato with H2O2 gives rise to two PtIV isomers. Carboxylation of the OH groups with anhydrides yields two isomeric dual-action PtIV prodrugs that than can be isolated and differ in lipophilicity and cytotoxicity. With phenylbutyrate as the bioactive ligand, the symmetric ctc-[Pt(NH3)2(OH)2(OAc)2] was more cytotoxic than the nonsymmetric isomer in four cancer cell lines.

[Communications]
D. Khattib, M. Ishan, Dr. S. Karmakar, Dr. H. Kostrhunova, Prof. V. Brabec, Prof. D. Gibson
doi.org/10.1002/chem.202001472

Steering Site-Selectivity in Transition Metal-Catalyzed C−H Bond Functionalization: the Challenge of Benzanilides

7 July, 2020 - 00:00

Full control of the site-selectivity in C−H bond functionalization is as desirable as challenging in transition-metal catalysis. This is especially true for benzanilide derivatives, which are one of the most important building blocks in organic synthesis. The developments of these methodologies are discussed emphasizing the action mode that the transition metal-based catalysts display in order to reach a given site-selectivity.

[Reviews]
Dr. Rafael Gramage-Doria
doi.org/10.1002/chem.202000672

Targeting an Interaction Between Two Disordered Domains by Using a Designed Peptide

7 July, 2020 - 00:00

Towards peptide therapeutics : The peptide p53 linkTer has been designed based on the p53 linker disordered domain, derived from its two termini. It binds the disordered RT loop in iASPP with the same affinity as the parent p53 linker peptide, thereby inhibiting the interaction between iASPP and p53, leading to cancer cell death. This peptide, comprising only the intrinsically disordered part of a parent peptide sequence, binds its target protein without pre-folding to a defined conformation.

[Full Papers]
Guy Mayer, Zohar Shpilt, Shachar Bressler, Orly Marcu, Prof. Ora Schueler-Furman, Prof. Edit Y. Tshuva, Prof. Assaf Friedler
doi.org/10.1002/chem.202000465

Peptidyl Vinyl Ketone Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment

7 July, 2020 - 00:00

Novel Michael acceptors targeting rhodesain, the main cysteine protease of T. brucei rhodesiense have been developed. Starting from findings reported by us in the literature, modifications at the P2 position led to inhibitors that showed picomolar K i values against rhodesain, endowed with appreciable selectivity towards the target enzyme and antitrypanosomal activity in sub-micromolar order of magnitude.

[Full Papers]
Dr. Santina Maiorana, Prof. Roberta Ettari, Dr. Santo Previti, Dr. Giorgio Amendola, Dr. Annika Wagner, Prof. Sandro Cosconati, Prof. Ute A. Hellmich, Prof. Tanja Schirmeister, Prof. Maria Zappalà
doi.org/10.1002/cmdc.202000360

Short Photoswitchable Antibacterial Peptides

7 July, 2020 - 00:00

Potent potential : Three short peptides with an azobenzene photoswitch incorporated either on a side chain or the C-terminus allow reversible switching between the cis- and trans-enriched photostationary states. All trans-enriched states were more potent against S. aureus than their cis-enriched counterparts, with the peptide modified at the C-terminus exhibiting the greatest antibacterial activity (MIC=1 μg/mL).

[Communications]
Yuan Qi Yeoh, Dr. John R. Horsley, Jingxian Yu, Dr. Steven W. Polyak, Dr. Blagojce Jovcevski, Prof. Andrew D. Abell
doi.org/10.1002/cmdc.202000280

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