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A sweet flow: HMF production and in situ valorization into valuable nitrile-containing compound via telescopic flow chemistry
DOI: 10.1039/D5GC04694G, PaperJulián E. Sánchez-Velandia, Mattia Annatelli, Cristopher Tinajero, Marcileia Zanatta, Victor Sans, Fabio Aricò, Eduardo García-Verdugo
Where sweet meets smart materials and flow chemistry: flowing sugars into sustainable chemical value by means of task-specific ionic liquid and telescopic process.
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A strategy of H-bond confinement catalysis for efficient degradation of polyethylene glycol into glycol diester over an OH-functionalized ionic liquid
DOI: 10.1039/D5GC05259A, PaperXiaoqian Chang, Yunpeng Xu, Chunliang Hou, Ruihan Wang, Xiaoyang Chang
This study innovatively utilized the H-bond confinement and synergistic catalytic mechanism of [HO-EtMIm][OTf] to efficiently activate benzoic anhydride and PEG, achieving an efficient degradation reaction under metal- and solvent-free conditions.
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Upcycling lithium extraction by-products from spent lithium-ion batteries into high-voltage polyanionic LiMnxFe1−xPO4
DOI: 10.1039/D5GC03642A, PaperFan Xiao, Lehan Zhu, Zhangjun Wu, Haotian Zhu, Juan Xia, Jiannan Zhu, Zeheng Yang, Weixin Zhang
This article presents the conversion of the low-value by-products FePO4 and MnO2 from lithium extraction of spent LIBs into high-performance LiMnxFe1−xPO4 cathode, providing a cost-effective upcycling route for sustainable lithium-ion batteries.
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Exploring the environmental and economic performance of fluorinated intermediates in pesticide manufacturing: a life cycle assessment perspective
DOI: 10.1039/D5GC04729C, PaperYunzhi Zhao, Tianzuo Zhang, Jinglan Hong, Ruiqi Jin, Xiaotian Ma
This study established the first LCA database for China's fluorinated intermediates and revealed their green production routes.
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An ion-pair as a superacidic precatalyst for the synthesis of indole alkaloids: a novel entry into the Fischer indole synthesis
DOI: 10.1039/D5GC04707B, PaperPooja Sivaganesan, Chibisree Elanchezhian, Diksha Bansal, Mrinal Kanti Das, Saikat Chaudhuri
The first ion-pair-catalysed Fischer indole synthesis is disclosed, powered by the superacidic [Ph3C]+[B(C6F5)4]− system as the pre-catalyst. The method introduces a powerful tool for the synthesis of indole alkaloids with exceptional efficiency.
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Electrochemical nitrogen oxide formation from ammonia and dinitrogen
Green Chem., 2026, Accepted Manuscript
DOI: 10.1039/D5GC05480J, Perspective
Open Access 
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Peter Jungbacker, Ruud Kortlever, Fokko M. Mulder
Synthetic fertilizers are required to sustain the increasing human population. Out of the many different types of fertilizers, ammonium nitrate is the most widely used type. Currently, both compounds are...
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DOI: 10.1039/D5GC05480J, Perspective
Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Peter Jungbacker, Ruud Kortlever, Fokko M. MulderSynthetic fertilizers are required to sustain the increasing human population. Out of the many different types of fertilizers, ammonium nitrate is the most widely used type. Currently, both compounds are...
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The Complex Interplay of Chemo- and Bio-catalysis for One-pot Oxidation Cascades – Indole Oxidation in Focus
Green Chem., 2026, Accepted Manuscript
DOI: 10.1039/D5GC05367F, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alex Stenner, Richard Lewis, Johnathan Pask, David John Morgan, Thomas Davies, Graham Hutchings
The combination of chloroperoxidase (CPO), derived from the marine fungus Caldariomyces fumago, in combination with supported AuPd nanoalloys, has been demonstrated as a highly efficient one-pot system for the selective...
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DOI: 10.1039/D5GC05367F, Paper
Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alex Stenner, Richard Lewis, Johnathan Pask, David John Morgan, Thomas Davies, Graham HutchingsThe combination of chloroperoxidase (CPO), derived from the marine fungus Caldariomyces fumago, in combination with supported AuPd nanoalloys, has been demonstrated as a highly efficient one-pot system for the selective...
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Solvent-Free In Situ Self-Nanoemulsifying Dissolving Microneedles for Rapid and Safe Transdermal Treatment of Acute Pain with Plant-Derived Eugenol
Green Chem., 2025, Accepted Manuscript
DOI: 10.1039/D5GC06106G, PaperPeiya Shen, Chengxiang Luo, Jiaqi Liu, Desen Wang, Jianjun Zhang, Mi Tang, Shuai Qian, Yuan Gao, Yuanfeng Wei
Acute pain treatment is often limited by delayed onset and gastrointestinal side effects of NSAIDs, as well as the addiction potential of opioids. Eugenol (EUG), a natural plant-derived compound with...
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DOI: 10.1039/D5GC06106G, PaperPeiya Shen, Chengxiang Luo, Jiaqi Liu, Desen Wang, Jianjun Zhang, Mi Tang, Shuai Qian, Yuan Gao, Yuanfeng Wei
Acute pain treatment is often limited by delayed onset and gastrointestinal side effects of NSAIDs, as well as the addiction potential of opioids. Eugenol (EUG), a natural plant-derived compound with...
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Using green deep eutectic solvents for targeted regeneration to improve the cycle life of spent lithium iron phosphate batteries
DOI: 10.1039/D5GC04838A, PaperJin Wu, Lin Chen, Ruichao Zhu, Yixuan Zhou, Chuqing Cao, Liang Zhu, Jun Zhang
Developing an eco-friendly, recyclable ternary deep eutectic solvent to achieve structural restoration and performance enhancement of waste lithium iron phosphate.
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Green pathways to low-sulfur diesel: advances and challenges in desulfurization technologies
DOI: 10.1039/D5GC04160K, Tutorial ReviewPeiwen Wu, Shaojie Ma, Wenshuai Zhu
Comprehensively reviews HDS and emerging non-HDS methods, highlighting green strategies and future directions for ultra-clean diesel production.
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A Green Chemistry Approach to the Synthesis of an Emerging Drug for the Treatment of Celiac Disease
Green Chem., 2025, Accepted Manuscript
DOI: 10.1039/D5GC05246G, PaperChandler B. Nelson, Kaitlyn M Frieberg, Jordan R Yirak, Max Baumann, Bruce H. Lipshutz
A sustainable synthesis of ZED1227, a new drug for treaCng Celiac disease, is reported. The route avoids waste-generaCng processes resulCng in an overall E-Factor that reflects reliance on technologies that...
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DOI: 10.1039/D5GC05246G, PaperChandler B. Nelson, Kaitlyn M Frieberg, Jordan R Yirak, Max Baumann, Bruce H. Lipshutz
A sustainable synthesis of ZED1227, a new drug for treaCng Celiac disease, is reported. The route avoids waste-generaCng processes resulCng in an overall E-Factor that reflects reliance on technologies that...
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In-situ Growth of Indium-doped Cerium Oxide for Highly Selective Urea Electrosynthesis from Nitrate and Carbon Dioxide
Green Chem., 2025, Accepted Manuscript
DOI: 10.1039/D5GC04834F, PaperYifan Zhou, Shuying Li, Yuxia Jin, Rui Yang, Peng Luo, Changrui Feng, Ziyuan Yang, Abuliti Abudula, Peifen Wang, Wenhao Lian, Guoqing Guan
Urea electrosynthesis through nitrate and carbon dioxide offers a sustainable alternative to traditional energy-intensive Bosch-Meiser process for urea production. This process enables decentralized production using renewable electricity while mitigating two...
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DOI: 10.1039/D5GC04834F, PaperYifan Zhou, Shuying Li, Yuxia Jin, Rui Yang, Peng Luo, Changrui Feng, Ziyuan Yang, Abuliti Abudula, Peifen Wang, Wenhao Lian, Guoqing Guan
Urea electrosynthesis through nitrate and carbon dioxide offers a sustainable alternative to traditional energy-intensive Bosch-Meiser process for urea production. This process enables decentralized production using renewable electricity while mitigating two...
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Chemical recycling of polycarbonate waste into advanced aviation fuel candidates via nickel–oxygen vacancy dual sites
DOI: 10.1039/D5GC04561D, PaperYushuang Huang, Jiawei Xie, Yisong Zhou, Qianqian Song, Yuan Lei, Chang-an Zhou, Chao Wang, Kui Ma, Lei Song, Hairong Yue, Ji-Jun Zou
Cost-effective Ni/CeO2 catalysts with nickel–oxygen vacancy dual sites enable the upcycling of PC waste into advanced aviation fuel-range hydrocarbons and their strong resistance to coke formation ensures stability and reusability.
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Cascade synthesis of diarylamines catalyzed by oxygen-rich and porous carbon
DOI: 10.1039/D5GC05166E, Paper
Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anna Lenarda, Itisha Jain, Aleksi Kaleva, Valtteri Oksanen, Sami Heikkinen, Risto Koivula, Tom Wirtanen, Michele Melchionna, Tao Hu, Juho HelajaPorous activated carbon bearing OH and CO groups, in the presence of a molecular oxidant, catalyzes metal-free cascade synthesis of diarylamines via enamine formation and oxidative aromatization.
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Eco-designed cellulose-reinforced deep eutectic gels with synergistic mechanical strength, ionic conductivity, and freezing tolerance for flexible electronics
DOI: 10.1039/D5GC05362E, PaperXiangyu Lin, Jie Li, Fei Fu, Ziming Zhu, Yuandong Xu, He Liu, Xu Xu
Eco-designed cellulose-reinforced deep eutectic gels with synergistic mechanical strength, ionic conductivity, adhesion and freezing tolerance for flexible electronics.
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Rapid proton transport through a bio-inspired PO4-built protective layer for stabilizing 5-hydroxymethylfurfural conversion at high current densities
DOI: 10.1039/D5GC04249F, PaperWei Ji, Wenjie Zhang, Chen Deng, Yuwei Xiong, Qi Hao, Hao Zhang, Bing Song, Wenlei Zhu, Dekui Shen, Jason Chun-Ho Lam, Richen Lin
PO4 built protective layers form fast proton channels that boost proton-coupled electron transfer while shielding catalysts from proton corrosion, enabling biomimetic electrocatalysts for high current, sustainable biopolymer electrosynthesis.
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Selective hydrodeoxygenation of lignin phenolics to cyclohexanols over low-Ru catalysts
DOI: 10.1039/D5GC04644K, PaperRumin Ma, Xueying Gao, Xiancheng Li, Shuizhong Wang, Guoyong Song
A low-loaded Ru catalyst efficiently and selectively converts a series of lignin-derived phenolics and bio-oil into cyclohexanols in water.
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Electrochemical reconstruction- and electronegativity-induced electron redistribution for activating sulfur atoms of MoOxSy-based materials toward efficient hydrogen evolution
DOI: 10.1039/D5GC03386A, PaperXiao-Yu Yang, Rui-Yuan Li, Zhan Liu, Chun-Mu Guo, Xiao-Yun Li, Cui-Fang Ye, Zhao Deng, Jia-Min Lyu, Ming-Hui Sun, Shen Yu, Yu Li, Yi-Yong Huang, Li-Hua Chen, Kai Liu, Bao-Lian Su, Yi-Long Wang
This work focuses on the development of a strategy for electrochemical reconstruction coupled with electronegativity to synergistically induce electron redistribution for the activation of sulfur atoms in MoOxSy-based materials toward efficient HER.
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Upcycling of polyethylene terephthalate to high-value chemicals by carbonate-interchange deconstruction
DOI: 10.1039/D5GC03354C, Paper
Open Access 
  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nicholas J. Galan, Isaiah T. Dishner, Bobby G. Sumpter, Vilmos Kertesz, Nabihan B. Abdul Rahman, Felipe Polo-Garzon, Zoriana Demchuk, Tomonori Saito, Jeffrey C. FosterCarbonates enable PET deconstruction to valuable terephthalate products with high selectivity and low solvent demand.
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Low indoor light-driven CO2 conversion into visible C4 bioplastic via homogeneous non-metal-based biohybrids under photoexcitation
DOI: 10.1039/D5GC02437D, PaperWenjing Wang, Mingzhi Zhang, Meng Guo, Jiaxin Wang, Xuelian Wang, Jianheng Yin, Liang Chen, Yaguang Li
A uniformly autotrophic K/O-CN–R. eutropha biohybrid was designed to efficiently convert CO2 into visible C4 bioplastics without the need for any auxiliary agents.
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