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Does the FDA's authorization for chloroquine impede clinical trials for COVID-19 drugs?

Chemical News - 28 aprile, 2020 - 19:05
Despite the hype, support for the use of chloroquine and its relative hydroxychloroquine outside a clinical trial remains mixed

Ancora coronavirus ed acque di scarico.

BLOG: LA CHIMICA E LA SOCIETA' - 28 aprile, 2020 - 13:11

Rinaldo Cervellati.

L’amico ed esperto Mauro Icardi ha già affrontato in dettaglio questo argomento sul blog, (https://ilblogdellasci.wordpress.com/2020/04/15/monitoraggio-del-coronavirus-delle-acque-reflue/ ed ancora https://wp.me/p2TDDv-4vU).

Ora anche negli USA arriva la notizia che il virus SARS-CoV-2, responsabile del COVID-19, è stato trovato nelle acque reflue, pertanto l’epidemiologia basata sulle acque reflue potrebbe essere un modo efficace per valutare l’estensione del contagio in una popolazione (Celia H. Arnaud, Novel coronavirus found in surprisingly high levels in sewage, Chem. & Eng. News, 20 aprile 2020).

L’epidemiologia delle acque reflue è comunemente usata per monitorare l’uso di droghe in una comunità, ma può anche fornire informazioni sulla diffusione di un’infezione quando i test vengono opportunamente impiegati. Un gruppo di ricerca, coordinato da Eric J. Alm del Massachusetts Institute of Technology e Biobot Analytics[1] hanno utilizzato la reazione a catena della polimerasi per trascrizione inversa (RT-PCR) per monitorare il virus SARS-CoV-2 nelle acque di un impianto di trattamento delle acque reflue nel Massachusetts.

Eric J. Alm

I ricercatori hanno pubblicato i loro risultati sul server di prestampa medRxiv (2020, DOI: 10.1101/2020.04.05.20051540 [1]), quindi lo studio non è stato ancora sottoposto a revisione (peer review).

Il gruppo di ricerca ha analizzato quattro campioni prelevati antecedentemente al primo caso statunitense noto di COVID-19 e tutti sono risultati negativi per il virus. Per contro, i 10 campioni prelevati tra il 18 marzo e il 25 marzo sono risultati positivi per SARS-CoV-2, a livelli superiori a quelli previsti dai ricercatori in base al numero di casi confermati. Essi hanno usato il sequenziamento diretto del DNA per verificare che i prodotti RT-PCR provenissero effettivamente dal SARS-CoV-2. Ma sono necessarie ulteriori informazioni, come la quantità di virus nelle feci di pazienti positivi nel corso della malattia, per interpretare appieno i risultati.

Kevin Thomas, un epidemiologo dell’Università del Queensland (Australia) afferma “l’analisi delle acque reflue “potrebbe essere utilizzata per stabilire se COVID-19 ha infettato una comunità e valutare il momento in cui la comunità sarà relativamente libera dal virus, l’approccio dovrebbe comunque essere usato in combinazione con test individuali”.

Kevin Thomas e il suo gruppo di ricerca.

Secondo Marianna Mathus, Amministratore Delegato di Biobot, la Compagnia sta ricevendo campioni settimanali da oltre 100 impianti di trattamento negli Stati Uniti.

[1] https://www.medrxiv.org/content/10.1101/2020.04.05.20051540v1

Al link si trova subito l’avviso: Questo articolo è una prestampa e non è stato sottoposto a revisione. Riporta nuove ricerche mediche che devono ancora essere valutate e quindi non dovrebbero essere utilizzate per la pratica clinica.

[1] Biobot Analytics è una Società di epidemiologia delle acque reflue che sta trasformando le sue infrastrutture in osservatorio di sanità pubblica.

During the coronavirus pandemic, hospitals have taken unprecedented steps to disinfect N95 face masks

Chemical News - 27 aprile, 2020 - 23:50
With protective equipment in short supply, health-care facilities are decontaminating and reusing items designed to be disposable

Incinerators may spread, not break down PFAS

Chemical News - 27 aprile, 2020 - 23:38
Preliminary data show soil and water near New York facility are contaminated

A new electricity-boosting effect seen in perovskites

Chemical News - 27 aprile, 2020 - 12:45
This photoflexoelectric effect could lead to devices that harvest energy from both light and motion

Rome Therapeutics launches to probe junk DNA for cancer drug discovery

Chemical News - 27 aprile, 2020 - 12:21
Biotech veteran Rosana Kapeller co-founded the start-up, which raised $50 million to develop small-molecule drugs

COVID-19 is reshaping the pharmaceutical supply chain

Chemical News - 27 aprile, 2020 - 07:00
The coronavirus pandemic may mark a rebalancing of where drugs are made as nations recognize a security imperative

Chemistry educators try ‘ungrading' techniques to help students learn

Chemical News - 27 aprile, 2020 - 01:43
The approach aims to give STEM students more dialogue in their education and free them from the constant pressure of assessment

Video: Mucus inspires sticky, stretchy, antibacterial material

Chemical News - 27 aprile, 2020 - 01:42
Made with bacteria-killing carvacrol oil, the new substance might be used as an adhesive or coating

Silicon-carbonyl complex is stable at room temperature

Chemical News - 27 aprile, 2020 - 01:42
Electron-rich compound reacts like a transition metal

Hollow MoS<sub>3</sub> Nanospheres as Electrode Material for “Water-in-Salt” Li-Ion Batteries

Articles from Wiley - 27 aprile, 2020 - 00:00

A WISE choice: Hollow MoS3 nanospheres are synthesized via a scalable template-based method to be used as anode for Li-ion batteries (LIBs) using “water-in-salt” electrolytes (WISE). High specific capacity and excellent stability are achieved in WIS-LIBs and the working mechanism of MoS3 in aqueous LIBs is reviewed.

[Articles]
Ting Quan, Dr. Yaolin Xu, Dr. Michael Tovar, Dr. Nicolas Goubard-Bretesché, Dr. Zhaolong Li, Dr. Zdravko Kochovski, Dr. Holm Kirmse, Kai Skrodczky, Dr. Shilin Mei, Dr. Hongtao Yu, Dr. Daniel Abou-Ras, Dr. Marnix Wagemaker, Prof. Yan Lu
doi.org/10.1002/batt.202000042

Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells

Articles from Wiley - 27 aprile, 2020 - 00:00

Site-specific targeting: Nitroaromatic prodrugs were activated by the bacterial nitroreductase NfsB (NTR) to selectively inhibit lysine-specific demethylase 1 (LSD1) in transfected leukaemic cells. The effects of LSD1 inhibition and cytotoxicity of the side products were distinguished by negative controls. This system may be applied in targeting approaches to reach site-specific LSD1 inhibition.

[Full Papers]
Eva-Maria Herrlinger, Mirjam Hau, Dr. Desiree Melanie Redhaber, Dr. Gabriele Greve, Dr. Dominica Willmann, Simon Steimle, Prof. Dr. Michael Müller, Prof. Michael Lübbert, Dr. Christoph Cornelius Miething, Prof. Roland Schüle, Prof. Manfred Jung
doi.org/10.1002/cbic.202000138

Optochemical Control of Protein Degradation

Articles from Wiley - 27 aprile, 2020 - 00:00

Stereochemistry matters: Optochemical approach has been used to regulate cellular protein degradation with a high resolution of spatiotemporal control. Two recent studies combining reversible optochemical functionalities with bifunctional proteolysis targeting chimeras, PHOTACs and photoPROTACs, are highlighted here to illustrate light-controlled degradation of desired protein.

[Highlights]
Dr. Peng Wu, Dr. Debasish Manna
doi.org/10.1002/cbic.202000113

Recent Development of Photothermal Agents (PTAs) Based on Small Organic Molecular Dyes

Articles from Wiley - 27 aprile, 2020 - 00:00

Photothermal therapy being a noninvasive cancer therapy, there is intense interest in synthesizing highly efficient PTAs that can convert light into heat. In this paper, we highlight recent developments in PTAs based on small-molecule dyes and discuss the main factors limiting their translation into clinical applications.

[Minireviews]
Shibo Lv, Yuyang Miao, Dr. Dapeng Liu, Prof. Fengling Song
doi.org/10.1002/cbic.202000089

Electronic Modulation between Tungsten Nitride and Cobalt Dopants for Enhanced Hydrogen Evolution Reaction at a Wide Range of pH

Articles from Wiley - 27 aprile, 2020 - 00:00

Co doped WN nanowire arrays grown on a carbon cloth are prepared by a facile hydrothermal method and the result shows that the Co dopants can effectively downshift the position of d-band center of W sites as a result of the electron transfer from W to Co thereby decreasing adsorption energy of H on W in Co/WN. Consequently, both of the modulated W and introduced Co dopants facilitate the HER process.

[Communications]
Zhizhong Liu, Prof. Xuming Zhang, Dr. Hao Song, Yixuan Yang, Dr. Yang Zheng, Dr. Biao Gao, Prof. Jijiang Fu, Prof. Paul K. Chu, Prof. Kaifu Huo
doi.org/10.1002/cctc.202000391

Electroless Plating of Transition Metal Boride with High Boron Content as Superior HER Electrocatalyst

Articles from Wiley - 27 aprile, 2020 - 00:00

Hydrogen evolution reaction: A strategy of electroless plating of transition metal boride with high boron content to fabricate binder-free catalytic electrode with superior HER activity has been realized.

[Full Papers]
Ruiqi Zhang, Huixiang Liu, Chenfeng Wang, Dr. Lincai Wang, Dr. Yanjing Yang, Dr. Yanhui Guo
doi.org/10.1002/cctc.202000315

Recent Advances in C−H Functionalization with Electrochemistry and Various Iodine-Containing Reagents

Articles from Wiley - 27 aprile, 2020 - 00:00

Forming bonds: Organic electrochemistry provides new opportunities for the assembly of various chemical bonds in an environmentally friendly manner. This Minireview summarizes recent advances in electrocatalytic C−H functionalization with various iodine-containing reagents from 2009 to 2019. Previous reports in this field are descried based on the categories of C−X (X=C, N, O, S, etc.) bond formation. The synthetic procedures and possible reaction mechanisms are discussed to provide a better understanding for readers.

[Minireviews]
Dr. Peng Qian, Prof. Zhenggen Zha, Prof. Zhiyong Wang
doi.org/10.1002/celc.202000252

A Critical Analysis about the Underestimated Role of the Electrolyte in Batteries Based on Organic Materials

Articles from Wiley - 27 aprile, 2020 - 00:00

The importance of the electrolyte: Redox active organic materials are currently considered as very interesting candidates for the realization of sustainable energy storage devices. This review aims to supply a critical overview about the work carried out so far on the development of electrolytes suitable for these materials.

[Minireviews]
Patrick Gerlach, Prof. Dr. Andrea Balducci
doi.org/10.1002/celc.202000166

Synthesis and SAR of Tetracyclic Inhibitors of Protein Kinase CK2 Derived from Furocarbazole W16

Articles from Wiley - 27 aprile, 2020 - 00:00

No get-together: Tetracyclic inhibitors of the protein-protein interaction of the protein kinase CK2 subunits to form the tetrameric holoenzyme have been developed. Particular attention was paid to the stereochemistry and the group X resulting in furo- and pyrrolocarbazoles. Some furocarbazoles showed PPII in the low-micromolar range, inhibition of the tetrameric holoenzyme and weak inhibition of two subunits.

[Full Papers]
Dr. Lukas Kröger, Dr. Constantin G. Daniliuc, Deeba Ensan, Sebastian Borgert, Dr. Christian Nienberg, Miriam Lauwers, Dr. Michaela Steinkrüger, Prof. Joachim Jose, Dr. Markus Pietsch, Prof. Bernhard Wünsch
doi.org/10.1002/cmdc.202000040

Discovery of New Antiproliferative Imidazopyrazole Acylhydrazones Able To Interact with Microtubule Systems

Articles from Wiley - 27 aprile, 2020 - 00:00

Two imidazopyrazole carbohydrazides were identified as potential anticancer drugs by preliminary screening of a large library of small molecules against NCI 60 panel cell lines. Further analyses showed their ability to induce apoptosis and affect cell-cycle phases. Immunofluorescence analysis, tubulin polymerization assays and a docking study suggest that the mechanism of action involves the microtubule system.

[Full Papers]
Prof. Chiara Brullo, Dr. Federica Rapetti, Prof. Silvana Alfei, Dr. Irena Maric, Dr. Francesca Rizzelli, Dr. Marina Mapelli, Dr. Camillo Rosano, Dr. Maurizio Viale, Prof. Olga Bruno
doi.org/10.1002/cmdc.202000122

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